Italy, 1456. The Renaissance is in glorious bloom, an age of unbridled creativity, commerce, art, and innovation. One of the most colorful men of this astonishing time is Fra Filippo Lippi, equally revered as a painter and reviled as a rogue. A great artist, he serves Cosimo de' Medici and the Catholic Church, creating masterpieces in celebration of God and His glory. A Carmelite monk, he acts as chaplain to the nuns of the Convent Santa Margherita--and it is here, behind the cloister walls, that he encounters the greatest temptation of his life.

Penniless and beautiful, young Lucrezia Buti has been driven to Santa Margherita more by poverty than piety. Mesmerized by Lucrezia's flawless features, Lippi sees in her face the inspiration for countless Madonnas. With the help of his powerful friends and an unscrupulous prioress, he draws upon favors that will lead to dangerous consequences, and brings the young woman to his studio to serve as his model.

Painter and muse are soon united in an exhilarating whirl of artistic discovery. As weeks and months pass, a passionate love develops between the irascible artist and the young nun, resulting in a scandalous romance that threatens to destroy them even as it fuels some of Lippi's greatest work. Their affair sparks anger, envy, and vengeance . . . and it will take a miracle of undying faith, unsurpassed beauty, and unfathomable love to save all that Lippi and Lucrezia cherish.